Theoretically it should remained full of water......As you mentioned earlier with the diagram above with the "up and over" setup it could be possible for the siphon to be broken. I honestly wouldn't 100% safely say that it would remained primed or would I rely on that setup. That setup is known/has created issues with getting the pumps primed.
An idea I would have is building or creating out of PVC, using basically a "T" type fitting attaching to the pump, but allowing a cap to be used and accessed in the design that you could add water; flooding the pump with water. Honestly if your in an area that is prone to power outages I would do something else.
Curiousity has peaked my interest, so how big of a tank are we talking about and what is the height from the sump back to the tank? 2500gph is a lot of water to have entering the tank, as well as running through the sump. I'm curious as to why such a big pump, and 6' really isn't tremendious, and depending on the size tank, as I'm sure you already know and has been mentioned you theoretically only want/need 3-5x tank turnover rate through the sump.