Good bio-balls in a system with proper flow will handle ammonia and nitrite as well as LR. However, as mentioned above, they will do nothing for nitrate. Nitrate can be much higher in a fish-only tank than a reef; but the bio-balls still need regular RINSING. Do not scrub them, I've seen this suggested many times. The slime coat on the balls houses the friendly bacteria. IMO & IME; in a fish-only system; any type of good outside filter (bio balls, canister, big HOB, etc) will be completely adequate for ammonia/nitrite control. Aerobic bacteria (to control ammonia & nitrite) is very easy to culture; bio-load should never be a problem in an established tank---stocked with common sense. I'm always amazed how often folks have ammonia show up in a long-established tank.