Change it as per the directions on the bottle.
I love it. Don't try to use it to stop doing water changes, still change water as your nitrate levels dictate. Although... I had a Tomato Clown, without a mate, lay eggs every 2 weeks in water that hadn't had a change in long enough to... well... if I told you I would get flamed along the lines of being called either a liar or a bad influence and that I don't know what I'm doing.
ChemiPure is just a deionizer, it's like constantly running your tank through a DI unit.