Yes, Cu is bad for reef systems and B-ionic does contain copper in it, but I am sure that they are in trace amounts. I think everyone takes Cu a little to seriously. Any one of those metals on the back on the B-ionic part 2 bottle could be toxic at high concentrations, especially at the concentration at which we use to treat fish with parasites. You have to realize that transition metals such as copper are required for almost all biosynthetic processes in an organism. The control of electrons is regulated by these metals and that is why they are included in B-"ionic" to control the ionic balence in the system. Don't worry too much about it. It's there for a reason.