I'm not sure I can answer that. I am experimenting myself. However, I thought I wanted enough to fill in all of the little pockets around the crushed coral. This would decrease water motion and create the beneficial anaerobic zones which should decrease nitrates. So far, it seems like a 1:1 mix appears okay.
I have a mixture of Figi and Tonga Branch live rock. The Fiji is much more porous. Initially I liked that much more as it seemed to have more life on it. However, I am now wondering whether the Tonga Branch is able to create its own anaerobic zones which may be removing my nitrates. I am happy I don't have a problem but realize that if I did develop one I could 1)remove my current substrate, possibly putting it through a sieve, 2)add more sand (either in the tank or in a refugium) or 3) set up a refugium.
I think that the difference in size of grains on the sand bed is actually more natural in appearance than just all sand.
Your tank - your choice.