I am in the low income housing business, and us "slum lords" know each other. One of the other landlords uses 1/4 inch plexi glass for windows, and knowing my SWF hobby, asked me if I wanted the scraps. I picked up a pile of 1/4 in acrylic for free and went to experimenting. So far I have made 2 refugiums, a breeder/HOB fuge, and a housing for my MH ballasts. Oh, and a cake plate for Mrs rangermonroe. But that is the limit to my experience. I really liked the WELD-On, but I did use silicone on the end panel of the first fuge. So far with no problems.
If you are going to use silicone, first make sure that both surfaces are very clean. Have rags/ paper towels handy, (this is a messy operation) and attach peices with a continuous bead. To smooth out the bead, I use dishwashing soap in a cup to dip my finger in so the silicone doesn't stick to me. Clean up any "oops" before it dries, because you will need a razor to clean it up afterwards. Razors and acrylic dont mix...the blade will gouge it and it will be unsightly.
If you notice on the photo, I placed a cross brace in the center top...ie, no bowing at all.
Silicone from lowes should pose no threat of leaching after it cures 24/48 hours.