I have 2 separate tanks on my 135. A 29 gallon refugium, and a converted ecosystem sump.(It's just an ecosystem without anything in the refugium compartment.)
I am running two separate return pumps with an OF feeding each tank. Left side feeds the fuge, right side feeds the sump. They are connected with a U tube of PVC, primed with an aqualifter to insure I don't get a syphon break. This is just to balance them out. It is working flawlessly now for several months.
If all my flow went through the U tube, I probably wouldn't need the aqualifter.