my clown is an absolute a s s. he chases and hates everything and anything that gets within 4" of his anenome. however, he doesn't leave the area ever so i'd say heck yeah a 46gal should be perfectly fine. he never seriously nips at other fish, just chase. little dog complex and when i say "he" i mean "whatever it is" interesting as hell tho, and i'd buy another for every other tank if i had the money.