As the others have said... LS with regular sand is fine, just put the LS on top of the regular sand. If possible, try to find non-silicate based regular sand (Southdown tropical play sand from Home Depot is a popular one). When placing the LR, it doesn't matter if you put it on top of the sand or on the bottom of the tank with the sand around it. However, if you put it on top of the sand, make sure you press it down into the sand a bit to make sure it's good and sturdy. As your tank develops you will probably get creatures that can topple rockwork if it doesn't have a good, stable base.