I would try to keep my nitrates under 20 max, and better under 10 in a reef. A FOWLR
(Fish Only With Live Rock) gives you more leeway...probably try to keep under 40-50 range though I know of some fish only tanks with higher nitrates.
If you need to do large water changes to get the nitrates down that is OK (large meaning
50%) as long as same SG, pH, temperature water that you are replacing.
Also, if you are having chronic high nitrate problems you need to figure out why...
Some (but not all) possibilities
Tank not fully cycled
crushed coral versus sand substrate
feeding too much
too many fish
bioballs in a wet/dry filter
nitrates in you 'new' water
Ways to get nitrates down
water changes
macroalgae that removes nitrates
deep sand beds
decreasing amount of fish or increasing amount of water (adding sump)
decreased feeding
water changes