I use Weld-on #4 and # 16, both made by IPS. I've built 20g, 40g and smaller tanks, I've built tanks in the shape of a triangle, a weird little nano refugium, and I am planning my big tank right now(shooting for the 300g size) I tape the acrylic together how i want it(using electrical tape) then I use the #4 thin weld with an insulin needle and inject it along the seems. After that I go back with the #16 and fill in any where I missed with the thick stuff. If I am building a big tank I do just the opposite I use the thick stuff first, and fill in with the thin, and little pieces of shavings.