Plan on changing out about 5 gals a day for hypo on that size tank, otherwise you will never get to hyposaline conditions.
The skimmer won't work well, if at all, as the water becomes less saline. You will have to rely on mass water changes to keep ammonia and nitrites down. Take a look at the QT info in the FAQ Thread if you haven't already.
What are you using to measure salinity? If it is a plastic swingarm hydrometer, then it will not do. Also take a look at the info on refractometers in the FAQ Thread.