No, the layout is the same, the PS3 controller just have that built-in six-axis stuff that's never been fully utilized. IMO, the PS controllers are terrible, mainly only because of one reason, the position of the left thumbstick. For any type of a lengthy constant use, like for racing games, it gets uncomfortable if you have larger hands. And if you tell me to use the D-pad, you have no business playing racing games....
I would say 360. PS has lost it's hold on exclusive games. Really, any good games are available for the 360 as well, and usually they have been debuting on the 360 first. I prefer the 360 because of it's exclusive games, namely Halo and Forza.