If you cut the glass yourself you could do it that way, but you might want to have the edges of the glass bevel cut, so don't know if you could do that yourself though.... I know first hand it's pretty expensive in my area to get a replacement panel for a tank like that....Acrylic would probably be a whole lot cheaper and easier to work... The thing with with doing it in acrylic is getting bubble free joints, and that is a tedious, but if you check out melevsreef site you will get alot of good helpfull tips and hints for a good bubble free joint..... Sounds like an interesting project!!!!!