This is going to be a really stupid answer but . . . . its just like a bigger tank only smaller.
Seriously . . . the only difference is that you cant "forget" to do something such as top off, dose, or a water change. There is less room for error.
If you are dedicated to doing it, there is no more difficulty involved (said with caution) than a larger tank.
Try the mini-bow 7 gallon tank made by All-Glass. REALLY nice nano tank set up!