I made a DIY overflow for my tank, in the process of getting it to match (stayahead of) the flow rate of my return pump I was up to 3 one inch U tubes, which worked fine.
Then in the never ending process of trying to improve the system, I switched to 1-1/4" U tubes, and started to have the same "air bubble/lose siphon" trouble your talking about.
I then removed one of the tubes to increase flow through the other two ( effectivly increasing flow rate through the tubes, which is inline with what broomer5 is saying) and I no longer have the bubble problem and still have enough flow to keep up with return pump.
Do you have a two tube or three tube system? Maybe playing with number of tubes and/or size of tubes will help.