In my personal experience, I would think it wise to take out 25 percent of the water once a month; which has worked fine. However for a reef, the chemisty portions MUST BE PERFECT or you may find your prized possesions destroyed. THus, I would recommend taking out a 5 to 10 percent water change weekly. THis way you will get that clean water you want and still not destroy the wonderful creation you created. Now you will realize as you progress on this wonderful journey that you will not need water changes when your aquarium becomes a complete cycled. FOr that is the only word I could use to explain it. But heed my words, while your tank is 'cycling' getting all the chemistry perfect... DO NOT DO WATER CHANGES!!! Doing so may damage the cycle.