The closest thing I have for comparison. The Penn State tank (96x42x30 ~530gal) has the main return "T"ed off and goes into PVC nozzles at either side of the tank pointing down/out and length-wise of the tank. There are three other closed-loops. Two pump to 1" seaswirls in the front corners of the tank, and the third to PVC nozzles at the front of the tank pointed out/down/back. In addition to that there are two modded maxijets mounted on the overflow box blowing parallel to the back panel behind the rockwork. There is also a Tunze stream (not sure of the model) mounted in the back right corner.
So yes, a larger tank's flow can be provided without using a rediculous number of powerheads, but you have to be creative about it. You won't be able to completely remove powerheads from the tank though. IMO the best way to go about this is a return with nozzles pointed down along the top perimeter of the tank, a closed loop with nozzles hidden under the rockwork and powerheads at either end (Vortechs preferablly). Make use of seaswirls. Powerful uni-directional flow is not as nice medium intensity random flow.