From my experiences GOOD LUCK tryin to do this, glass is o.k with glass using silicone,, however silicone no matter what kind( ive tried them all i beleive)will not stick to acrylic or plexi, evan if you let the dry for weeks. I have heard that if you scuff the plexi up it might stick( with sandpaper or soemthing) but i doubt this will work too.. Acrylic to Acrylic or pleaxi is easy using Weld-On 16 or 4,, if you need more info on this just let me know