I like using it in my acclimation bucket, but that is about it. Some of the stress coats on the market (such as Kent Marine's stress coat) will make your skimmer foam like crazy. I used it one time on my 75 and it had such a drastic effect on the skimmer, I could not turn the skimmer on for two weeks. I did two 20% water changes and it was still not out of the water. It was filling up my skimmer cup with foam/water in under 15 seconds.