just did a quick little search and found something you might find usefull, if you havent already considered this.
"When drilling plumbing holes (or holes on the top for feeding access) the best tool is a holesaw, the kind used for putting in deadbolts/doorknobs. When using one, make sure you use plenty of water, these get very hot and will literally melt themselves to the hole. Start by drilling about 1/8" into one side, then flip the acrylic over and drill out the hole, this will keep the acrylic from splintering-out or cracking along the hole edge. Remember to have the plastic supported underneath."
I never wouldve considered the heat when drilling acrylic, but it does make sense.