I, like angie use the garlic that is in gel tabs and also the kind from the grocery store (McCormic brand). I've had great results. I soak brine once a week as a prevenitive mesure. I would suggest using at first signs of an outbreak(one or two speks on fish) The general concensis (sp) is that it is totally reef safe. I haven't had any problems t all using garlic. If you want more info i would suggest doing a search on "garlic". Also, i suggest using vitamins to soak most of your food in. I have heard and found for myself this to be the best prevenitive mesure in controling ick outbreaks along with low stress in the tank. HTH