I'm planning on knocking a hole in my wall in the next couple of weeks. I don't see any real disadvantage as long as you plan properly. I've looked at some freinds tanks, and hopefully learned from some of their mistakes. 1 freind of mine put a 300, but didn;t leave enough room at the top to easily access the tank. Another freind put his filtration in place, then built around that. Problem with that is if he ever needs to remove anything its a pain. Just try to keep in mind that you'll want to be able to access every part of the system easily. Heres a pic of my freinds 300.