Most problems people have from sealing a tank is improper prep work and impatience. You have to cut away all the old caulk, then clean the glass (maybe with an acetone) with something that will dissolve the caulk. Clean and DRY it with a glass cleaner. The surface must be DRY and so must the cracks. Don't use a high heat hair dryer though or you may crack the glass.
Also use 100% silicone caulk made for agauariums... every company GE, DAP, who ever will tell you they have one for that... they lie. All those have fillers and herbicides in the make up and will not stand up to salt water. Pay more, its not worth saving $10 and risk $1000's on livestock.
Recaulk. Let stand for 48 hours (not 24 like it says) You want to make sure that the caulking has completely cured. Also you don't want alot of excess caulking (1/4 " bead is more than enough) and be sure you have pressed it into the corners well.
Now that you've used some really nasty chemicals it's best to run fresh water in the tank ( I put mine in the yard and ran a hose through it for about 3 hours. Then I filled it up again with fresh water and ran 2 PH and a magnum with fresh carbon in it for 5 days. Changed water and repeated.
Never had a problem with it since (75 gal)
Sorry for the length. Good luck!