It depends on how much L/R you have.
If you have 1 to 1 1/2 pouns per gallon
IMO you would not even need to start with any bioballs. The L/R and L/S is enough!
But if you started with them and have plenty of L/R then I would remove them slowly.
You could also leave them in but they can be a nitrate trap. I really can'tsay from experience
if it is bad to have them. I just know you can start and maintain a reef without them!!!