I don't know about the nano cube, but I had the biocube you're looking at. My BIGGEST thing about it was that the lid was not hinged to the tank. I didn't think it was a big deal when I first saw the tank, boy was I wrong. It was a pain for anything that didn't fit in the feeding square. If you moved the top even the slightest bit, it got off center and was a bit of a job to get it just right and back on. Besides that...absolutely nothing! The back area of the tank is nice, and can fit a lot of things in it. The acrylic was nice...but it was beveled. I liked the way it looked but it made pictures hard to take.