No. Puffers and triggers often don't mix. Also, don't mix non aggressives (tangs) with aggressives. Puffers also don't often mix well with each other. Good choices for your tank would be groupers, eels, large wrasses/hogs, triggers, puffers, hamlets, lionfishes, and some other odds and ends. I think I read you have a 220, so do some reading, find some fish you like, and shoot them by us. Bo