Well, to start out, Puffers are only poisenous if you ingest their skin, so u need not worry about that, unless one dieds and yer fish decide to peck at its skin. Also, theya re not reef safe at all. They will eat almost ALL inverts, will bite and chomp on corals and cause disaster. Although they are cool, FISH ONLY COMMUNITY. LOL, have a nice day.:happy: