The media that you have in your canister does not absorb. It provides surface space for nitrifying bacteria to grow and is designed to mechanically capture detritus. This is not absorbing. LR and sands, on the other hand, are porous and can retain the medication. If your canister had carbon, then this would be an absorbing material, and would need to be removed during a mediction treatment.
Think of it this way. If you pour grape juice on a sponge, it will be absorbed in the sponge. However, if you pour spaghetti boiled in water in a metal caldren, the caldron holds on to the spagetti but the water passes thru. The caldron absorbs absolutely nothing. Some materials in our filters absorb [like the sponge], and some block and capture [like the caldron]. Some do both.
As far as your canister is concerned it is fine for a QT. Even carbon has a short life as a mechanical/chemical filter [3 wks]. If carbon has been in use in your filter for a few wks, I wouldn't bother removing it for medication treatments. In fact, Carbon, after a few wks, goes from being a highly effective absorbing filter to a biological filter.
Sand is another whole ball game here. Sand is a biological filter as well as mechanical filter. If you have 3 inches of sand down in a QT that is functioning both as a biological filter [nitrifying bacteria] and a mechancial filter [waste trap] that is dependent upon the biological filter [to export/remove the waste] what will happen when you add copper or antibiotics or any med to the sandbed???
It will kill your sandbed's biological filter. Now, you have a dead sandbed devoid of biological filter. What happens to the waste in the sandbed?? See what what I mean? Understand now why we say no substrate?