I calibrate or at least clean mine every month or water change when I use it.
If you test your water and then set your refractometer down the the salt will dry onto the lens, you can have residual salt even if you just wipe it. Then next time your readings could be off.
Or testing from one tank to another, you wouldn't just leave the water on from the last tank and then put a few drops from another tank on there would you?
Get it?
Thomas