I would have to say it would depend on the dimensions of the refugium.
if I could readily fit large LR into it then I would go with mostly larger LR. and let the macro grow amongts it. if I was limited for space I would go purely macro. in my 30g sump I run sand, macro, and LR in my 10G sump I run mostly macro. (there is some lr in there but not a lot due to space limitations and equipment). it would also depend on how much I could invest in my refugium, for low $$ I would run macro its cheaper and grows on its own so you can start with a very little and end up with more than you need.