I have drilled five tanks now. From an 1/8 thick glass to a 3/8 inch thick glass. With the proper drill bit, setup, which needs to be very stable, like a drill press you can position the tank properly for it is very easy really. Just take your time. You are not really drilling, which is quite different from what you have done drilling wood or metal. You are GRINDING AWAY GLASS so that you leave a hole when you are done GRINDING, not drilling.
I did the first hole I drilled on a ten gallon tank, with 1/8 inch glass, using a MOTOTOOL with a diamond bit, by hand... It took about 20 minutes. The key is go SLOW and easy.
But it not the daunting experience some would have you believe. Just make sure you get the proper tools, and understand that you are GRINDING, not DRILLING... and take your TIME...
Dave