Originally Posted by rbaldino
Well, in my experience, there are things that can end up on the substrate that the cleanup crew may never touch, like clumps of algae, food that didn't get eaten, stuff that falls off of rock, etc. It's just my experience that cleaning the upper substrate will cause no real harm, certainly no more than a sand sifting fish or invert, and is sometimes desireable for aesthetic purposes.
Which brings up another good question. If you have a sand sifting fish or a snail that hides in the sand and if you don't clean it won't the "trates" in the sand kill the fish?