I suppose it depends on how much flow your UV can handle, yes. But my understanding is that UVs need very low flow in order to assure that the water has sufficient contact time with the UV light for the light to penetrate and kill the microorganisms you're trying to eliminate. At the same time, it needs to be high enough to cycle your water through frequently, so it's a bit of a balancing act.
You should read the book that comes with your UV, but mine (a small turbotwist) requires flow of 100-200gph. So for my application, I just set up a small second pump down in my sump that feeds the UV constantly. So it's not UV treating the water as it passes back into the tank, but it is nevertheless treating the water all the time and killing stuff.
Also, be sure you plumb it so that fairly clean water is going through it. You want it to be killing microorganisms, not getting gunked up with debris from the water.