I was perhaps too vague... my apologies. Copper can indeed disrupt the bioligical function if not use properly.... There can be some die off of the bacteria but again, if used properly this shouldn't be a problem. If a tank has never been "coppered" before you would want to start off with prolly half of what the mfg recommends dosage wise.... monitoring ammo, 'trites, an 'trates the first few days... if any of these levels start to rise significantly then you need to stop dosing and let the levels adjust.
Copper binds with calcerous substances, i.e. your rocks and sand. It can never really be truly removed from the system. You should never ever dose copper in any tank containing live rock,sand... or even dead decorative coral skeletons UNLESS this tank is to be strictly a FISH ONLY tank......
I used to work at a shop years ago and we only sold saltwater fish and related equipment....NO corals, NO rock... our system (and although I do not agree with doing so but hey , not my store) was permanently coppered... and I assure you, there was indeed biological filtration taking place. Ever see a wet/dry filter that holds about 500 gallons of bio-balls? It's purty big! hehehe