The wheel can be rinsed in tank water, just like bioballs. The arguement with biowheels is the same as with bioballs, the basic idea is that the bacteria that consume nitrate (they live deep in a sand bed or in LR) preferentially use nitrate produced nearby in the surface layers of sand/rock...and not more distant sources (the biowheel).
BUT, nitrates are FAR less toxic than ammonia, so the trade off is this question "do you want the security of having an efficient filter to quickly act on ammonia, or the risk of having a longer ammonia spike?" The disclaimer, IMO is that this pertains primarily to young tanks that still face instability issues, without a lot of LR, and with the high potential of overstocking and overfeeding. In mature tanks, I don't think it is as much of a question.
There is, IMO, no harm in them BUT, they may not be necessary if you have significant LR in the tank and the tank is mature. If you develop a nitrate problem, then the biowheels may be one of several things to think about...but first things would be feeding, overstocking and maintenance.