DerrickT
You can successfully run any saltwater tank without any substrate should you desire.
As long as you provide sufficient biological filtration for the fish you have - it can be done, and has been done by many folks for years.
You will not have the denitrification benefits of a living DSB.
You will not have the diversity of life in a bare bottom tank as compared to a tank with a living DSB.
You will not have the huge surface area for bacteria to grow in a sandless bottomed tank as you would with a living DSB.
You will not gain many of the benefits of having a living DSB - one of which is more free time not consumed by unnecessary tank care and cleaning/maintenance.
With a bare bottom ( or minimum substrate ) tank - depending on your fish load - you will need to deal with nitrate build up either with a DSB refugium or algae planted refugium ...
OR
Do more frequent water changes to reduce nitrates.
You will need to occasionally siphon off the visible debris and detritus that will fall to the bottom of a tank with no substrate ( or little substrate. )
There is little time spent cleaning a DSB - almost none - aside from reaching in occasionally to remove something by hand if you care to.
Personally - The additional time spent doing more nitrate reducing water changes and cleaning the bottom of a bare bottom tank is not what I consider "user friendly" tank care maintenance.
With a DSB and a good clean-up crew, and all the critters that live down in the sandbed - you can literally go weeks/months without ever having to stick your hand in to reach the bottom of the tank.
DSB's are by far much easier to keep, provide many benefits to the tankwater chemestry, fish, inverts and all living creatures much more, and is just a less demanding tank to care for in my opinion.
But ... as always ... it's your choice to make