the only thing it seems to mess with is the protein skimmer, for about a week(the time i used it) my skimmer blew white bubbles but after running carbon to get rid of the yellow it was fine, but then again im stuck with a seaclone skimmer,
also i adapted my style of using it, when i feed my fish i put it in with thier food(crush the pill into powder and slightly wet) and then feed them, it seems to work quicker that way, also supplementing with garlic helps