It's advised every 3-6 months depending on your usage/preference, to flush out the RO membrane to help prolong it's life. The flush valve allows you to flush out the membrane without disconnecting everything. Personally, I disconnect the membrane anyways.
I have a General-Water bay-of-e unit, I've replaced the RO membrane, replaced the DI section with a 10" unit, as well as the prefilters, all from the filterguys.
75gpd membrane
* 1 POLY SEDIMENT FILTER 1 MICRON
* 1 MATRIKX CTO/2 CARBON BLOCK FILTER
* 1 MATRIKX +1 CARBON BLOCK FILTER
THE TIDE SINGLE DI SYSTEM