I went from a 28G JBJ, to a 180G DT with a 105G Refuge
No regrets here, opened the door to alot more things, more and better fish, corals, etc.
the only drawback is cost, of course with size, there is an increase in cost. If you can afford it, then go for it.
The only thing I would suggest is don't go for cheap... I see fellow reefers trying to go BIG on a budget, DON'T do that... you will just be frustrated and most likely unsuccessful. Go for good equipment, lights, etc.