Unless you have a lot of experience, and a really established tank where you know how to balance the chemical reactions, then I wouldn't suggest it. However, on the other hand, there are people out there who have done some pretty impossible things. You could have one in a small tank with a really super large sump to make up for the water volume difference. Nems have to have really clean water and a ton of light to survive. Most lights put off too much heat in small aquariums - with too large of temp swings to keep them alive.
just my .02