I've found that running at 1.020 to 1.021 is a good range for FO systems. It doesn't wipe out parasites, but I believe it really limits their propogation. The parasites in tanks do best at the natural salinity level too, and they are frankly much more sensitive than fish, so it does help some. To severely cut down on them, you'd need to go lower... say 1.012-1.014, but I wouldn't risk my expensive fish to that. Fish stores frequently run that low, but consider how long the fish remain in their systems...
Lower salinities will also save you money on salt... some... but one dead fish caused by it will probably eat up a years worth of savings.