With lots of LR and a big wetdry plus a big skimmer yes.That is pretty much the bioload Ive been running for several years with no problems.I would problably leave one of the first two tangs out . Ive got the naso ,PBT,lion ,SFE ,Clown trigger and a butterfly so it is possible. I have several pics. in the aggressive forum of this 9 year old tank.