no idea, my valentini puffers fins got all cloudy or something, i wasnt really trying to get rid of a disease i was trying to lower nitrates wich i think were the cause of what was wrong. Anyways my fish are healthy and doing well. I have no idea what was wrong because my nitrates are still around 80ppm. I figured the nitrates would go down quicker doing large weekly or so water changes. My question is how long should i wait untill i do a large water change and how often should i do it?