MINOCYCLINE:
USE: Minocycline hydrochloride, also known as Minocycline, is a member of the broad spectrum tetracycline antibiotics, and has a broader spectrum than the other members, especially as to gram negative bacteria. Minocycline is also synthetic whereas Tetracycline Hydrochloride and Oxytetracyline are naturally occurring. It should also be noted that Minocycline maintains serum levels 2-4 times that of most other tetracyclines (150 mg giving 16 times the activity levels compared to 250 mg of Tetracycline Hydrochloride at 24-48 hours).
It has excellent anti-inflammatory properties which makes it a good choice for septicemia, although for Viral Septicemia there is no effective treatment, only prevention. Minocycline is also effective for fin/tail rot and OCCASIONALLY pop eye and is sometimes suggested for dropsy. However as for Dropsy I strongly recommend against this as this antibiotic can cause severe kidney damage.
Minocycline is skin absorbed like Kanamycin (although not as well) which can increase effectiveness. It is also nontoxic to invertebrates but should not be used in Marine aquaria.
Minocycline, like Tetracycline, becomes dangerous past its expiration date. Minocycline can be more toxic over time. Minocycline (like other Tetracyclines) is easily absorbed by calcium, making this a poor choice for saltwater or high GH freshwater aquariums (such as African Cichlids, livebearers), in these cases Kanamycin is the better choice.
This point is often missed by well meaning aquarists (often in many forums that love to recommend Maracyn-2), Maracyn–Two (Minocycline) is a good product when used in the right conditions for the right problem (of which it is relatively wide spectrum), the problem is that most aquariums I have either encountered or have read the water parameters for have too high of minerals (GH over 200) for Minocycline to be truly effective, in fact there in lies the problem in that often these minerals that render Maracyn Two less effective IMPROVE the fish’ natural ability to fight disease.
With these points in mind, generally the ONLY aquaria I recommend Minocycline in are Amazon River tanks such as Discus Aquariums.
DOSAGE: Maracyn-Two is the primary source for this anti-biotic, follow directions given by Mardel (manufacturer of Maracyn –2)
KANAMYCIN SULFATE (Kanaplex)
ABOUT/ USE: An easily absorbed antibiotic, it is used to treat many sensitive gram–negative and some gram–positive bacteria. Kanamycin is a water-soluble aminoglycoside antibiotic that is derived from the bacterium Streptomyces kanamyceticus and has a very low adsorption rate in the intestine of animals including fish. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides such as Kanamycin are especially useful in infections involving aerobic gram-negative bacteria such as Columnaris.
Kanamycin works especially well in salt water aquariums. Kanamycin works well combined with (& compliments) Nitrofurazone for flexibacter (Columnaris). Also useful for Pseudomonas-Open red sores or ulcerations, fin and tail damage, fins and tail are eaten away, in severe cases, down to the body. Kanamycin is very effective in high pH applications, especially Vibrio, making it useful for brackish and marine treatments. Kanamycin is easily absorbed skin absorbed, making it an excellent choice for systemic infections.
Kanamycin is one of the more effective broad spectrum antibiotics available with recent test showing it to surpass the Tetracycline class antibiotics in cultures including Minocyline (found in Maracyn 2), although Kanacyn has been also been shown in these studies to be even more effective when combined with other antibiotics such as Nitrofurazone or Tetracyclines for a “super” antibiotic effect.
Kanamycin can also be used for aquatic Tuberculosis, although Isoniazid is often the drug of choice, both can be used together as Isoniazid seems to affect certain active TB bacterium whereas Kanamycin has often different TB activity effectiveness.
I personally have found this to be one of the more effective antibiotics available (similar properties to Chloramphenicol, although still not as effective as Chloramphenicol which is no longer available in the aquarium trade).
DOSAGE: 250-500 mg per 20 gallons. Treat every 48 hours with a 25% water change before each treatment. Treat for 10 days. Kanamycin is found in: SeaChem; Kanaplex