Absolutely, this is how I ran my 40G and how I'm currently running my 155. You need a hang on overflow box - CPR makes the best one, seriously, spend a little money now and save a lot later and you won't have a flooded carpet.
Then you just need a return pump. I actually run my 155 with a CPR hang on overflow, down to my sump and refugium, and a return back to tank as well as a fluval canister filter.