Some people need to look at a map before chiming in. El Cahon is a suburb of San Diego.
Santa Barbra is at least 4 hours away by car.
Aquarium of Pacific is in Long Beach and 2 hours away, not worth it in opinion.
Don't let the boys fool you into Blacks Beach, it is clothing optional.
SD Zoo is one of the finest in world. Near by is Balboa Park with some neat museums and gardens.
La Jolla is nice to visit, kind of like Rodeo Drive on the water.
Pacific Beach (PB) and Mission Beach (MB) are neat to visit, more casual...
TJ (Tiajuna) isn't worth the risk..
Seaport Village in downtown San Diego is a nice tourist trap to visit. Nearby is the USS Midway that you can tour if anyone in your family is into aircraft carriers or military planes.
Gaslamp district in downtown is fun for night life.
Old Town, just north of downtown is where to go for your Mexican dinner.
You must have In N Out burgers while there, they will put your Watta Burger to shame. Try a cheese burger animal style...
If the Padres are in town, their new downtown ball park is nice.
If your sister has to work and you want to get around town, the Trolley system is pretty good. From El Cahon you can get to all the places I mentioned above except for La Jolla, Pacific / Misson Beach by trolley. I think $5 gives you unlimited rides all day.
Have fun,
Chris