chamber 1 or intake chamber I have the sponge that came with the cube. I cut it in half. under that I have a bag of chemi-pure.
chamber 2: rock rubble, chaeto,heater
chamber 3: return pump more rock rubble
I don't think it is necessary to change your setup. That being said it is impossible for me know every setup and the effect this skimmer might have on them. The most important thing to do is maintain water levels in the back chambers. Because all the evap takes place back there I seem to do more top offs than I did without it.
Bob